单细胞测序技术的诞生，对于探索生命奥秘而言，是革命性的突破。从此，我们可以研究组织内每一个不同细胞的基因组，转录组，甚至是多组学的系统研究。此外，随着空间技术的发展，我们还可以测定组织中所有细胞的空间属性和相互作用。如今，这些技术广泛应用于肿瘤，免疫，神经，生殖，药物研发等领域，引领一波又一波的基础和临床医学的技术革命！
如今，单细胞及空间测序技术百花齐放，很多公司推出了自己的相关产品，市场一片繁荣的景象。而在这众多的单细胞及空间测序技术当中，10x Genomics的技术可谓是独树一帜。据10x Genomics官方统计，截止2021年11月初，10x Genomics单细胞及空间多组学技术已经助力全球科学家发表文章超过3000篇。可以用“一直被模仿，从未被超越”来形容10x Genomics在业界的地位！
如果您想搜索10x Genomics技术发表的文献，您可以登陆10x Genomics的官方网站（具体链接：https://www.10xgenomics.com/resources/publications），并且可以通过关键词，搜索某一物种，或者具体组织类型，研究方向等发表的文章。
在这些发表的文献当中，单细胞转录组测序技术的文章最多，但随着免疫研究的热度逐渐攀升，近两年单细胞免疫组研究的文章也越来越多了。此外，利用单细胞技术进行转录组 染色质可及性的研究也崭露头角。而空间转录组技术文章在今年更是一篇接一篇的见刊。相信在明年，空间转录组的文章将会掀起一波小高潮。并且从文章中所研究的单细胞数量来看，未来更高通量的单细胞研究将成为大势所趋，而10x Genomics推出的Chromium X 将满足大家对超高通量的需求。
在这里，小编也很高兴的告诉大家，截止11月初，中国科学家利用10x Genomics技术发表的文章也突破了300篇。真是可喜可贺！
中国科学家利用 10x Genomics 技术发表的文献列表
题目 | 期刊 | 影响因子 | 发表日期 | 研究内容 |
Integrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamics | PNAS | 9.58 | July, 2017 | 人胎盘组织细胞异质性 |
Dr.seq2: A quality control and analysis pipeline for parallel single cell transcriptome and epiGenome data | Plos one | 2.776 | July, 2017 | 开发了单细胞数据QC的方法和分析pipeline |
The Apostasia genome and the evolution of orchids | Nature | 41.577 | Sep, 2017 | 组装拟兰花基因组 |
Pulmonary alveolar type I cell population consists of two distinct subtypes that differ in cell fate | PNAS | 9.58 | Jan, 2018 | 研究人肺泡细胞的不同亚型 |
Draft genome of the Peruvian scallop Argopecten purpuratus | Gigascienc | 7.267 | Apr, 2018 | 组装扇贝基因组 |
Single-Cell RNA-Seq Reveals Dynamic Early Embryonic-like Programs during Chemical Reprogramming | Cell Stem Cell | 21.464 | July, 2018 | 研究在化合物诱导的重编程过程中，细胞所处的不同状态 |
The opium poppy genome and morphinan production | Science | 37.205 | Aug, 2018 | 组装了罂粟的基因组 |
Single-cell RNA-seq analysis maps the development of human fetal retina | bioRxiv | NA | Sep, 2018 | 研究人胚胎期视网膜细胞的发育 |
Draft genome of Glyptosternon maculatum, an endemic fish from Tibet Plateau | Gigascienc | 7.267 | Sep, 2018 | 组装藏鮡骨鱼的基因组 |
PDGFRβ Cells Rapidly Relay Inflammatory Signal from the Circulatory System to Neurons via Chemokine CCL2 | Neuron | 14.403 | Sep, 2018 | 研究脑组织的急性感染 |
Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells | Genome Medicine | 8.898 | Sep, 2018 | 研究小鼠Treg细胞在免疫耐受方面的功能 |
VASC: Dimension Reduction and Visualization of Single-cell RNA-seq Data by Deep Variational Autoencoder | Genomics, Proteomics & Bioinformatics | 6.597 | Dec, 2018 | 单细胞转录组数据分析方法的文章，解决基因dropout问题 |
Single-cell transcriptome provides novel insights into antler stem cells, a cell type capable of mammalian organ regeneration | Functional & Integrative Genomics | 2.745 | Jan, 2019 | 研究鹿角干细胞的再生 |
Comparative Analysis of Droplet-Based Ultra-High-Throughput Single-Cell RNA-Seq Systems | Molecular Cell | 14.248 | Jan, 2019 | 对比不同单细胞平台的优劣，包括10x， inDrop和Drop-seq |
Single-cell transcriptomes reveal molecular specializations of neuronal cell types in the developing cerebellum | JMCB | 4.671 | Jan, 2019 | 研究小鼠小脑发育过程中的神经细胞类型， |
Cell Fate Determining Molecular Switches and Signaling Pathway in Pax7-expressing Somitic Mesoderm | bioRxiv | NA | Jan, 2019 | 研究胚胎发育 |
The sequence and de novo assembly of hog deer genome | Scientific Data | 5.929 | Jan, 2019 | 组装豚鹿基因组 |
Defining multistep cell fate decision pathways during pancreatic development at single-cell resolution | The EMBO Journal | 9.792 | Feb, 2019 | 研究胚胎期小鼠胰腺细胞的发育，发现ERK pathway的活性对alpha和beta胰腺细胞的分化有重要作用 |
Resolving Cell Fate Decisions during Somatic Cell Reprogramming by Single-Cell RNA-Seq | Molecular Cell | 14.248 | Feb, 2019 | 在转录因子或化合物诱导的体细胞重编程过程中，对细胞命运决定起关键作用的转录因子 |
Cell–cell communication old mystery and new opportunity | Cell Biol Toxicol | 5.097 | Feb, 2019 | 单细胞Review |
A component overlapping attribute clustering (COAC) algorithm for single-cell RNA sequencing data analysis and potential pathobiological implications | PLOS Computational Biology | 4.428 | Feb, 2019 | 数据分析文章，研究单细胞聚类方法 |
Single-cell RNA-seq of cultured human adipose-derived mesenchymal stem cells | Scientific Data | 5.929 | Feb, 2019 | 研究间充质干细胞的异质性，探索用于治疗疾病的潜力 |
Role of alternative polyadenylation dynamics in acute myeloid leukaemia at single-cell resolution | RNA Biology | 5.216 | Mar, 2019 | 研究AML白血病 |
A Single-Cell RNA Sequencing Profiles the Developmental Landscape of Arabidopsis Root | Molecular Plant | 9.326 | April, 2019 | 研究拟南芥根的异质性 |
SSCC: A Novel Computational Framework for Rapid and Accurate Clustering Large-scale Single Cell RNA-seq Data | Genomics, Proteomics & Bioinformatics | 6.597 | April, 2019 | 单细胞转录组数据分析方法，可以对大量细胞快速聚类 |
High-Order Correlation Integration for Single-Cell or Bulk RNA-seq Data Analysis | Frontiers in Genetics | 3.517 | April, 2019 | 单细胞转录数据分析方法，用于降噪和细胞聚类 |
Extensive exploration of T cell heterogeneity in cancers by single cell sequencing | Chinese Journal of Cancer Research | 2.515 | April, 2019 | Review，介绍单细胞测序技术在研究肿瘤内部T细胞异质性中的应用 |
Gossypium barbadense and Gossypium hirsutum genomes provide insights into the origin and evolution of allotetraploid cotton | Nature Genetics | 25.455 | April, 2019 | 做棉花基因组的组装 |
Sing cell RNA-seq reveals cellular diversity and developmental characteristics of human infant retina | bioRxiv | NA | April, 2019 | 研究婴儿视网膜细胞的异质性 |
Identification of a basal stem cell subpopulation in the prostate via functional, lineage tracing and single-cell RNA-seq analyses | bioRxiv | NA | April, 2019 | 研究前列腺基底干细胞 |
Characterization of dendritic cell subtypes in human cord blood by single-cell sequencing | Biophysics Reports | NA | April, 2019 | 研究人脐带血中的树突状细胞的亚型 |
Cell BLAST: Searching large-scale scRNA-seq databases via unbiased cell embedding | bioRxiv | NA | April, 2019 | 单细胞数据分析方法 |
Single-cell transcriptome-based multilayer network | Briefings in Bioinformatics | 6.302 | April, 2019 | 开发单细胞数据分析方法 |
A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis | Cell Report | 7.815 | May, 2019 | 斑马鱼造血干细胞 |
Dissecting the single-cell transcriptome network underlying gastric premalignant lesions and early gastric cancer | Cell Report | 7.815 | May, 2019 | 研究胃癌的早期病变 |
Genome assembly of a tropical maize inbred line provides insights into structural variation and crop improvement | Nature Genetics | 25.455 | May, 2019 | 组装玉米的基因组 |
Single-Cell Profiles and Clinically Useful Properties of Human Mesenchymal Stem Cells of Adipose and Bone Marrow Origin | The American Journal of Sports Medicine | 6.057 | May, 2019 | 研究脂肪组织和骨髓来源的间充质干细胞特征 |
Single-cell transcriptomic landscape of nucleated cells in umbilical cord blood | Gigascience | 7.267 | May, 2019 | 研究脐带血中有核细胞的异质性 |
VPAC: Variational projection for accurate clustering of single-cell transcriptomic data | BMC Bioinformatics | 2.511 | May, 2019 | 单细胞转录组数据分析方法的文章，提出了新的聚类方法 |
scRecover: Discriminating true and false zeros in single-cell RNA-seq data for imputation | bioRxiv | NA | June, 2019 | 单细胞转录组数据分析方法的文章，解决基因dropout问题 |
RobustClone: A robust PCA method of tumor clone and evolution inference from single-cell sequencing data | bioRxiv | NA | June, 2019 | 单细胞CNV数据分析方法，用于研究肿瘤进化 |
Proteomics and single-cell RNA analysis of Akap4-knockout mice model confirm indispensable role of Akap4 in spermatogenesis | Developmental Biology | 2.936 | June, 2019 | 研究睾丸中精子生成 |
The Cellular Diversity and Transcription Factor Code of Drosophila Enteroendocrine Cells | Cell Reports | 7.815 | June, 2019 | 研究果蝇肠内分泌细胞的异质性 |
A chromosome-scale genome assembly of cucumber (Cucumis sativus L.) | Gigascience | 7.267 | June, 2019 | 组装黄瓜基因组 |
The genome assembly and annotation of yellowhorn (Xanthoceras sorbifolium Bunge) | Gigascience | 7.267 | June, 2019 | 组装黄角花基因组 |
Vascularized human cortical organoids model cortical development in vivo | bioRxiv | NA | June, 2019 | 构建大脑皮层organoids模型 |
Inhibition of hyperglycolysis in mesothelial cells prevents peritoneal fibrosis | Science Translational Medicine | NA | June, 2019 | 研究腹膜纤维变性 |
Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma | Cell Research | 17.848 | July, 2019 | 研究胰腺导管癌 |
Comprehensive single-cell transcriptome lineages of a proto-vertebrate | Nature | 41.577 | July, 2019 | 海鞘胚胎发育单细胞转录谱 |
Single-Cell RNA-Seq of the Developing Cardiac Outflow Tract Reveals Convergent Development of the Vascular Smooth Muscle Cells | Cell Report | 7.815 | July, 2019 | 小鼠发育阶段心脏血管平滑肌细胞 |
An atlas of infiltrated B-lymphocytes in breast cancer revealed by paired single-cell RNA-sequencing and antigen receptor profiling | bioRxiv | NA | July, 2019 | 研究乳腺癌中浸润的B细胞 |
Single-cell transcriptome profiling reveals dermal and epithelium cell fate decisions during embryonic hair follicle development | bioRxiv | NA | July, 2019 | 研究胚胎期毛囊发育 |
Single-cell RNA sequencing profiling of the effects of aging on alveolar stem cells | Science China Life Sciences | 3.583 | July, 2019 | 研究肺泡干细胞 |
SET domain-containing protein 4 epigenetically controls breast cancer stem cell quiescence | Cancer Research | 9.13 | July, 2019 | 研究乳腺癌干细胞 |
Conversion of Astrocytes and Fibroblasts into Functional Noradrenergic Neurons | Cell Report | 7.815 | July, 2019 | 将星形胶质细胞和成纤维细胞转分化为神经细胞 |
The common neoantigens in colorectal cancer are predicted and validated to be presented or immunogenic | bioRxiv | NA | July, 2019 | 研究结直肠癌的抗原 |
Muscle-secreted G-CSF as a metabolic niche factor ameliorates loss of muscle stem cell in aged mice | bioRxiv | NA | July, 2019 | 研究肌肉干细胞 |
A draft genome for Spatholobus suberectus | Scientific Data | 5.929 | July, 2019 | 组装密花豆基因组 |
Optimal Gene Filtering for Single-Cell data (OGFSC)—a gene filtering algorithm for single-cell RNA-seq data | Bioinformatics | 4.531 | Aug, 2019 | 单细胞转录数据分析方法，用于降噪 |
Targeting Degradation of the Transcription Factor C/EBPβ Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages | Immunity | 21 | Aug, 2019 | 研究巨噬细胞在肺纤维化中的作用 |
Single-Cell Transcriptomic Map of the Human and Mouse Bladders | Journal of the American Society of Nephrology | 8.98 | Aug, 2019 | 人和小鼠前列腺单细胞分析 |
B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis | Nature communications | 11.88 | Aug, 2019 | 癌蛋白的寡聚化调控白血病的发生 |
Single cell transcriptomic landscapes of pattern formation, proliferation and growth in Drosophila wing imaginal discs | Development | 9.616 | Aug, 2019 | 研究果蝇翅膀器官芽 |
Single-Cell RNA-Seq Reveals Naïve B cells Associated with Better Prognosis of HCC | bioRxiv | NA | Aug, 2019 | 研究肝癌中的免疫细胞 |
A high-quality genome assembly for the endangered golden snub-nosed monkey (Rhinopithecus roxellana) | Gigascience | 7.267 | Aug, 2019 | 组装金丝猴的基因组 |
Single-cell landscape in mammary epithelium reveals bipotent-like cells associated with breast cancer risk and outcome | Communications Biology | NA | Aug, 2019 | 单细胞数据分析发掘 |
Single-cell RNA-seq highlights heterogeneity in human primary Wharton’s Jelly mesenchymal stem/stromal cells cultured in vitro | bioRxiv | NA | Aug, 2019 | 研究间充质干细胞 |
Activation of Hedgehog Signaling Promotes Development of Mouse and Human Enteric Neural Crest Cells, Based on Single-Cell Transcriptome Analyses | Gastroenterology | 20.877 | Aug, 2019 | 研究Hedgehog信号通路如何调节胚胎干细胞向肠神经嵴分化 |
K-mer counting with low memory consumption enables fast clustering of single-cell sequencing data without read alignment | bioRxiv | NA | Aug, 2019 | 单细胞数据分析方法 |
Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing | Cell Research | 17.848 | Sep, 2019 | 研究人胚胎期造血干细胞 |
Single-cell transcriptomic landscape of cardiac neural crest cell derivatives during embryonic and neonatal development | bioRxiv | NA | Sep, 2019 | 研究胚胎及新生小鼠心神经嵴细胞的发育 |
SciBet: a fast classifier for cell type identification using single cell RNA sequencing data | Nature communications | 11.88 | Sep, 2019 | 单细胞转录组数据分析方法的文章，利用已有数据的细胞注释结果，对新的数据进行注释 |
Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome | Genomics, Proteomics & Bioinformatics | 6.597 | Sep, 2019 | 组装汉族基因组 |
De novo assembly of a Tibetan genome and identification of novel structural variants associated with high altitude adaptation | bioRxiv | NA | Sep, 2019 | 组装藏族基因组 |
Chromosome‐level genome assembly of the razor clam Sinonovacula constricta (Lamarck, 1818) | Molecular Ecology Resources | 7.059 | Sep, 2019 | 组装剃刀贝基因组 |
Single-cell RNA-seq reveals RAD51AP1 as a potent mediator of EGFRvIII in human glioblastomas | Aging (Albany NY) | 5.515 | Sep, 2019 | 研究神经胶质瘤 |
Long-read assembly of the Chinese rhesus macaque genome and identification of ape-specific structural variants | Nature communications | 11.88 | Sep, 2019 | 组装猕猴基因组 |
Single-cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos | Immunity | 21 | Oct, 2019 | 构建了人类胚胎早期T淋巴细胞发育以及胸腺器官发生的分子图谱 |
Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling development | bioRxiv | NA | Oct, 2019 | 研究人视网膜发育 |
Proteasome inhibitor induced SIRT1 deacetylates GLI2 to enhance hedgehog signaling activity and drug resistance in multiple myeloma | Oncogene | 6.9 | Oct, 2019 | 研究骨髓瘤的耐药性 |
Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma | Cell | 36.216 | Oct, 2019 | 研究肝癌组织免疫微环境 |
Single-Cell Sequencing Reveals the Relationship between Phenotypes and Genotypes of Klinefelter Syndrome | Cytogenetic and Genome Research | 1.587 | Oct, 2019 | 研究克氏综合征 |
Enhancing single-cell cellular state inference by incorporating molecular network features | bioRxiv | NA | Oct, 2019 | 建立新的分析方法，研究细胞状态的改变 |
Zonation-dependent single-endothelial cell transcriptomic changes in the aged brain | bioRxiv | NA | Oct, 2019 | 研究脑组织衰老 |
Rapidly cycling stem cells regenerate the intestine independent of Lgr5high cells | bioRxiv | NA | Oct, 2019 | 研究小肠再生 |
CD24: a marker of granulosa cell subpopulation and a mediator of ovulation | Cell Death & Disease | 5.959 | Oct, 2019 | 研究卵巢颗粒细胞 |
Stress-Induced Metabolic Disorder in Peripheral CD4 T Cells Leads to Anxiety-like Behavior | Cell | 36.216 | Oct, 2019 | 研究CD4 T细胞嘌呤合成代谢功能紊乱与心理疾病联系 |
Synchronized replication of genes encoding the same protein complex in fast-proliferating cells | Genome Research | 9.944 | Nov, 2019 | 研究细胞增殖 |
Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways | Cell | 36.216 | Nov, 2019 | 研究小儿肠炎和炎症性肠病的发病机理及治疗方法 |
Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine | J Exp Med | 10.892 | Nov, 2019 | 研究人肠上皮细胞的异质性 |
Systematic comparative analysis of single-nucleotide variant detection methods from single-cell RNA sequencing data | Genome Biology | 13.214 | Nov, 2019 | 比较不同单细胞转录组测序方法在检测SNV方面的比较 |
HBsAg-specific CD8 T cells as an indispensable trigger to induce murine hepatocellular carcinoma | Cellular & Molecular Immunology | 8.213 | Nov, 2019 | 研究HBV病毒诱导肝癌的机制 |
Chemical Cocktail Induces Hematopoietic Reprogramming and Expands Hematopoietic Stem/Progenitor Cells | Advanced Science | 15.804 | Nov, 2019 | 研究化合物诱导的重编程 |
The Cellular Diversity and Transcription Factor Code of Drosophila Enteroendocrine Cell | Cell Report | 7.815 | Dec, 2019 | 研究果蝇肠道中内分泌细胞的亚型、分布、转录因子代码及信号调控机制 |
Single cell atlas of domestic pig brain illuminates the conservation and divergence of cell types at spatial and species levels | bioRxiv | NA | Dec, 2019 | 构建家猪脑组织单细胞图谱 |
AutoGenome: An AutoML Tool for Genomic Research | bioRxiv | NA | Dec, 2019 | 开发数据分析方法 |
WEDGE: recovery of gene expression values for sparse single-cell RNA-seq datasets using matrix decomposition | bioRxiv | NA | Dec, 2019 | 开发数据分析方法 |
Mapping Human Pluripotent Stem Cell Derived Erythroid Differentiation by Single-Cell Transcriptome Analysis | bioRxiv | NA | Dec, 2019 | 研究红细胞发育 |
Single-Cell Map of Diverse Immune Phenotypes in the Metastatic Brain Tumor Microenvironment of Non Small Cell Lung Cancer | bioRxiv | NA | Dec, 2019 | 研究脑瘤微环境中的免疫细胞 |
SCSA: a cell type annotation tool for single-cell RNA-seq data | bioRxiv | NA | Dec, 2019 | 开发数据分析方法 |
Single-cell transcriptomics reveals diverse and complex gene expression alterations in human trisomy 18 | bioRxiv | NA | Dec, 2019 | 分析18三体综合征 |
More than one antibody of individual B cells revealed by single-cell immune profiling | Cell Discovery | 4.6 | Dec, 2019 | 研究B细胞VDJ重排 |
A single-cell map for the transcriptomic signatures of peripheral blood mononuclear cells in end-stage renal disease | Nephrology Dialysis Transplantation | 4.198 | Dec, 2019 | 研究晚期肾病外周血单核细胞 |
A dominant autoinflammatory disease | Nature | 41.577 | Dec, 2019 | 研究RIPK1蛋白所导致的自身免疫性炎症 |
Progressive Pulmonary Fibrosis Is Caused by Elevated Mechanical Tension on Alveolar Stem Cells | Cell | 36.216 | Jan, 2020 | 研究特发性肺纤维化发病的机制 |
Arterial Sca1 Vascular Stem Cells Generate De Novo Smooth Muscle for Artery Repair and Regeneration | Cell Stem Cell | 21.464 | Jan, 2020 | 研究血管干细胞 |
Single-cell RNA sequencing of human kidney | Scientific Data | 5.929 | Jan, 2020 | 构建人肾脏单细胞图谱 |
Single-cell RNA sequencing analysis reveals alginate oligosaccharides preventing chemotherapy-induced mucositis | Mucosal Immunology | 7.352 | Jan, 2020 | 研究化疗引起的粘膜炎 |
Single-cell RNA-seq reveals endoimmune cells in zebrafish | bioRxiv | NA | Jan, 2020 | 研究斑马鱼血管内皮细胞 |
Decoding the development of the human hippocampus | Nature | 41.577 | Jan, 2020 | 研究人脑海马区的早期发育 |
Single-cell transcriptome analyses recapitulate the cellular and developmental responses to abiotic stresses in rice | bioRxiv | NA | Jan, 2020 | 研究环境因素对水稻发芽的影响 |
Single cell atlas of trisomy 21 cerebral cortex | bioRxiv | NA | Jan, 2020 | 研究21三体综合症胎儿大脑皮层 |
scTPA: A web tool for single-cell transcriptome analysis of pathway activation signatures | bioRxiv | NA | Jan, 2020 | 开发了一个网页版单细胞数据分析工具，可以研究信号通路的激活 |
Isolation and long-term expansion of a single adult human renal epithelial cell with efficient kidney regeneration capacity | bioRxiv | NA | Jan, 2020 | 研究肾脏上皮细胞在体外的再生能力 |
Noninvasive Prenatal Diagnosis for Duchenne Muscular Dystrophy Based on the Direct Haplotype Phasing | Prenatal Diagnosis | 2.4 | Jan, 2020 | 用于无创DMD诊断 |
A single-cell transcriptome atlas during Cashmere goat hair follicle morphogenesis | bioRxiv | NA | Jan, 2020 | 研究山羊毛囊生成羊绒的机制 |
A high-quality chromosomal genome assembly of Diospyros oleifera Cheng | Gigascienc | 7.267 | Jan, 2020 | 组装油柿基因组 |
Liquid Biopsy-Based Single-Cell Transcriptome Profiling Characterizes Heterogeneity of Disseminated | Proteomics | 3.106 | Jan, 2020 | 研究肺癌病人胸积水 |
Discovery of peculiar cells in the peri-tumoral regions and peripheral blood of glioblastoma patients by single cell RNA-sequencing | bioRxiv | NA | Jan, 2020 | 研究神经胶质瘤 |
Identification of a Zeb1 expressing basal stem cell subpopulation in the prostate | Nature communications | 11.88 | Feb, 2020 | 研究前列腺基底干细胞 |
Imputing Single-cell RNA-seq data by combining Graph Convolution and Autoencoder Neural Networks | bioRxiv | NA | Feb, 2020 | 研究单细胞数据分析方法 |
Global Dynamic Molecular Profiles of Stomatal Lineage Cell Development by Single-Cell RNA Sequencing | bioRxiv | NA | Feb, 2020 | 研究拟南芥幼芽 |
Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging | Cell | 36.216 | Feb, 2020 | 研究细胞节食对大鼠各器官的影响 |
The landscape of lung bronchoalveolar immune cells in COVID-19 revealed by single-cell RNA sequencing | bioRxiv | NA | Feb, 2020 | 第一篇用COVID-19病人样本做的文章，研究病毒引起的免疫反应 |
Single-Cell RNA Sequencing Reveals Size-Dependent Effects of Polystyrene Microplastics on Immune and Secretory Cell Populations from Zebrafish Intestines | Environmental Science & Technology | 7.14 | Feb, 2020 | 研究斑马鱼肠组织 |
scTSSR: gene expression recovery for single-cell RNA sequencing using two-side sparse self-representation | Bioinformatics | 4.531 | Feb, 2020 | 开发单细胞数据分析方法 |
Profiling ACE2 expression in colon tissue of healthy adults and colorectal cancer patients by single-cell transcriptome analysis | bioRxiv | NA | Feb, 2020 | 分析正常人结肠样本和结肠癌样本 |
Integrated decoding hematopoiesis and leukemogenesis at single-cell resolution and its clinical implication | bioRxiv | NA | Feb, 2020 | 研究造血和白血病发生 |
Spatiotemporal single-cell analysis of gene | Nature Neuroscience | 21.126 | Feb, 2020 | 研究小鼠视交叉上核 |
Characteristics, dynamic changes, and prognostic significance of TCR repertoire profiling in renal cell carcinoma patients | The Journal of Pathology | 6.253 | Feb, 2020 | 研究肾癌样本中TCR库 |
Single-cell ATAC-seq clustering and differential 2 analysis by convolution-based approach | bioRxiv | NA | Feb, 2020 | 开发单细胞ATAC数据分析方法 |
Single cell RNA-seq reveals the landscape of tumor and infiltrating immune cells in nasopharyngeal cancer | Cancer Letters | 6.491 | Feb, 2020 | 研究鼻咽癌组织中浸润的免疫细胞 |
Dissecting Esophageal Squamous-Cell Carcinoma Ecosystem by Single-Cell Transcriptomic Analysis | Cancer Cell | 22.844 | Feb, 2020 | 研究食管鳞状细胞组织中浸润的免疫细胞 |
Single-cell RNA sequencing of immune cells in gastric cancer patient | Aging | 5.515 | Feb, 2020 | 研究胃癌样本中的免疫细胞 |
Two waves of pro-inflammatory factors are released during the influenza A virus (IAV)-driven pulmonary immunopathogenesis | PLOS Pathogens | 6.1 | Feb, 2020 | 研究流感感染后的免疫反应 |
The Integrated Transcriptome Bioinformatics Analysis Identifies Key Genes and Cellular Components for Spinal Cord Injury-Related Neuropathic Pain | Front. Bioeng. Biotechnol | 4.2 | Feb, 2020 | 研究脊髓损伤相关的神经性疼痛的关键基因和细胞成分 |
Alginate oligosaccharides improve germ cell development and testicular microenvironment to rescue busulfan disrupted spermatogenesis | Theranostics | 8.7 | Feb, 2020 | 研究生殖细胞和睾丸微环境 |
Single cell RNA-seq reveals the landscape of tumor and infiltrating immune cells in nasopharyngeal carcinoma | Cancer Letters | 6.491 | Feb, 2020 | 研究鼻咽癌中的免疫细胞 |
Genetic characterization of stem cell-like cancer cell in the peri-tumoral regions and proliferative lymphocyte in the peripheral blood of patients with glioblastoma | bioRxiv | NA | Feb, 2020 | 研究神经胶质瘤患者肿瘤周围区域干细胞样癌细胞和外周血增殖淋巴细胞的遗传特征 |
Single-cell RNA sequencing of immune cells in gastric cancer patients | Aging | 5.515 | Feb, 2020 | 研究胃癌患者的免疫细胞 |
High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa | International journal of oral science | 2.79 | Feb, 2020 | 口腔黏膜上皮细胞中ACE2受体的表达 |
Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr Progenitors | Cell | 36.216 | Mar, 2020 | 研究胰岛类器官长期体外培养 |
Identifcation of a potential mechanism of acute kidney injury during the COVID-19 outbreak: a study based on single-cell transcriptome analysis | Intensive Care Medicine | 18.9 | Mar, 2020 | 研究COVID-19病人急性肾损伤的原因 |
DAISM-DNN: Highly accurate cell type proportion estimation with in silico data augmentation and deep neural networks | bioRxiv | NA | Mar, 2020 | 单细胞分析方法 |
Single-cell transcriptome profiling an adult human cell atlas of 15 major organs | bioRxiv | NA | Mar, 2020 | 人的细胞图谱，做了15组织 |
Single cell chromatin accessibility of the developmental cephalochordate | bioRxiv | NA | Mar, 2020 | 研究脊索动物的发育 |
Dimension Reduction and Clustering Models for Single-Cell RNA Sequencing Data: A Comparative Study | International Journal of Molecular Sciences | 4.3 | Mar, 2020 | 开发单细胞转录组数据分析方法 |
SCYN: Single cell CNV profiling method using dynamic programming | bioRxiv | NA | Mar, 2020 | 开发单细胞CNV算法 |
Single-cell transcriptomics of blood reveals a natural killer cell subset depletion in tuberculosis | EBioMedicine | 6.6 | Mar, 2020 | 研究结核病的NK细胞 |
Recapitulation of SARS-CoV-2 Infection and Cholangiocyte Damage with Human Liver Organoids | bioRxiv | NA | Mar, 2020 | 用人类肝类器官模拟SARS-CoV-2感染导致的胆管细胞损伤 |
Blood single cell immune profiling reveals the interferon-MAPK pathway mediated adaptive immune response for COVID-19 | bioRxiv | NA | Mar, 2020 | COVID-19病人免疫系统 |
Significant Evolutionary Constraints on Neuron Cells | Genome Biology and Evolution | 3.462 | Mar, 2020 | 数据分析方法 |
Single-cell RNA-seq data analysis on the receptor ACE2 | Frontiers of Medicine | 1.8 | Mar, 2020 | 研究新冠病毒感染各器官的风险 |
Complement Signals Determine Opposite Effects | Cell | 36.216 | Mar, 2020 | 研究B细胞在化疗治疗后的响应 |
Characteristics, dynamic changes, and prognostic significance of TCRrepertoire profiling in patients with renal cell carcinoma | Journal of Pathology | 5.78 | Mar, 2020 | 研究肾细胞癌患者TCR表达谱的特征，动态变化和预后意义 |
Single-cell RNA sequencing deconvolutes the in vivo heterogeneity of human bone marrow-derived mesenchymal stem cells | bioRxiv | NA | April, 2020 | 研究骨髓来源的间充质干细胞 |
Heterogeneity of exhausted T cells in the tumor microenvironment is linked to patient survival following resection in hepatocellular carcinoma | Oncoimmunology | 5.3 | April, 2020 | 研究肝癌病人中耗竭T细胞的异质性 |
Single-cell RNA-seq highlights | Stem cell research & therapy | 3 | April, 2020 | 研究脐带胶质来源的间充质干细胞的异质性 |
Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer | Cell | 36.216 | April, 2020 | 结肠癌细胞治疗 |
Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia | Aging and Disease | 4.1 | April, 2020 | 间充质干细胞治疗COVID-19 |
Single cell transcriptomics of human nephritis reveal the cellular origin of kidney disease associated genes | bioRxiv | NA | April, 2020 | 研究肾炎的致病机理 |
Revealing Cellular Heterogeneity and In Vitro Differentiation Trajectory of Cultured Human Endometrial Mesenchymal-like Stem Cells Using Single-cell RNA Sequencing | bioRxiv | NA | April, 2020 | 研究人子宫内膜间充质样干细胞的异质性和体外分化轨迹 |
Association Analysis of Single-Cell RNA Sequencing | Cells | 5.656 | April, 2020 | 研究骨骼肌发育 |
Single-cell transcriptome profiling reveals vascular endothelial cell heterogeneity in human skin | Theranostics | 11.556 | April, 2020 | 皮肤血管内皮细胞的组织特征及亚群异质性 |
Immune Cell Profiling of COVID-19 Patients in the recovery stage by Single-cell sequencing | Cell Discovery | 4.6 | May, 2020 | 研究COVID-19恢复期病人免疫系统 |
Genome and single-cell RNA-sequencing of the earthworm Eisenia andrei identifies cellular mechanisms underlying regeneration | Nature communications | 11.88 | May, 2020 | 研究蚯蚓的再生机制 |
Single-cell RNA-seq and V(D)J profiling of immune cells in COVID-19 patients | bioRxiv | NA | May, 2020 | 研究COVID-19病人免疫系统 |
Single cell chromatin accessibility of the developmental cephalochordate | bioRxiv | NA | May, 2020 | 研究女性生殖细胞发育 |
Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer | Cell Research | 17.848 | May, 2020 | 研究大肠癌中浸润的免疫细胞 |
Single cell RNA sequencing reveals regulation of fetal ovary development in the monkey (Macaca fascicularis) | bioRxiv | NA | May, 2020 | 研究猴子胎儿卵巢发育的调控 |
Potent Neutralizing Antibodies against SARS-CoV-2 | Cell | 36.216 | May, 2020 | 研究新冠病人体内广泛中和抗体 |
SCSA: A Cell Type Annotation Tool for Single-Cell RNA-seq Data | Frontiers in Genetics | 3.36 | May, 2020 | 开发单细胞注释方法 |
Single cell RNA sequencing of 13 human tissues identify cell types andreceptors of human coronaviruses | Biochemical and Biophysical Research Communications | 2.985 | May, 2020 | 分析不同组织中新冠病毒受体的表达 |
Trajectory and Functional Analysis of PD‐1high CD4 CD8 T Cells in Hepatocellular Carcinoma by Single‐Cell Cytometry and Transcriptome Sequencing | Advanced Science | 15.804 | May, 2020 | 研究肝癌组织中的T细胞 |
A single-cell transcriptomic landscape of primate arterial aging.pdf | Nature communications | 11.88 | May, 2020 | 研究动脉衰老 |
Aortic heterogeneity across segments and under high fat/salt/glucose conditions at the single-cell level | National Science Review | 16.6 | May, 2020 | 研究小鼠主动脉异质性 |
The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease | Cell Research | 17.848 | May, 2020 | 研究派杰氏病的患病机制 |
Increased Connexin36 Phosphorylation in AII Amacrine Cell Coupling of the Mouse Myopic Retina | Frontiers in Cellular Neuroscience | 3.9 | June, 2020 | 研究近视眼视网膜病变的机制 |
Adverse effects of nicotine on cardiogenic differentiation from human embryonic stem cells detected by single-cell RNA sequencing | Biochemical and Biophysical Research Communications | 2.985 | June, 2020 | 研究尼古丁对人心脏分化的影响 |
Single-cell Transcriptome Profiling reveals Dermal and | Theranostics | 8.7 | June, 2020 | 研究胚胎期毛囊发育 |
Single-cell transcriptome and antigenimmunoglobin analysis reveals the diversity of B cells in non-small cell lung cancer | Genome Biology | 10.8 | June, 2020 | 研究非小细胞肺癌中的B细胞 |
Single-cell transcriptional atlas of the Chinese horseshoe bat (Rhinolophus sinicus) provides insight into the cellular mechanisms which enable bats to be viral reservoirs | bioRxiv | NA | June, 2020 | 研究马蹄蝙蝠的单细胞图谱 |
Deciphering the Landscape of Peripheral Blood T Cells via Single-Cell RNA-Seq in Chronic Lymphocytic Leukemia | bioRxiv | NA | June, 2020 | 研究慢性淋巴细胞性白血病中的T细胞。 |
An entropy-based metric for assessing the purity of single cell populations | Nature communications | 11.88 | June, 2020 | 开发数据分析方法 |
Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing | Gut | 19.8 | June, 2020 | 构建胃癌单细胞图谱 |
Putative regulators for the continuum of erythroid differentiation revealed by single-cell transcriptome of human BM and UCB cells | PNAS | 9.58 | June, 2020 | 研究类红细胞分化的关键调控因子 |
Clustering and classification methods for single-cell RNA-sequencing data | Briefings in Bioinformatics | 8.99 | July, 2020 | 开发单细胞聚类方法 |
Normalizing single-cell RNA sequencing data with internal spike-in-like genes | bioRxiv | NA | July, 2020 | 开发单细胞数据均一化方法 |
Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients | Protein&Cell | 7.575 | July, 2020 | 研究COVID-19病人支气管肺泡上皮细胞 |
Single-cell landscape of immunological responses in COVID-19 patients | bioRxiv | NA | July, 2020 | 研究COVID-19病人免疫系统 |
HIT-scISOseq: High-throughput and High-accuracy Single-cell | bioRxiv | NA | July, 2020 | 研究角膜mRNA全长可变剪切 |
Single-cell sequencing reveals heterogeneity effects of bisphenol A on zebrafish embryonic development | Environmental Science & Technology | 7.149 | July, 2020 | 研究双酚A对斑马鱼胚胎发育的影响 |
High-dimensional single-cell analysis delineates | Cell Death and Disease | 5.91 | July, 2020 | 研究射频消融诱导的胰腺癌免疫微环境重塑 |
The molecular taxonomy of primate amygdala via single-nucleus RNA-sequencing analysis | bioRxiv | NA | July, 2020 | 研究灵长类杏仁核 |
Single-cell analysis reveals the function of lung progenitor cells in COVID-19 patients | bioRxiv | NA | July, 2020 | 研究COVID-19病人肺的多能功能干细胞 |
Single‐cell RNA sequencing reveals the landscape of early female germ cell development | FASEB Journal | 5 | July, 2020 | 研究女性早期生殖细胞发育 |
Unveiling transposable element expression heterogeneity in cell fate regulation at the single-cell level | bioRxiv | NA | July, 2020 | 研究细胞命运决定 |
Comparative analysis of cell lineage differentiation during | Cell Research | 17.848 | July, 2020 | 研究小鼠和人的肝脏发育 |
A single-cell transcriptome atlas of the aging human and macaque retina | bioRxiv | NA | July, 2020 | 人类和猕猴视网膜的单细胞转录组图谱 |
Searching large-scale scRNA-seq databases via unbiased cell embedding with Cell BLAST | Nature communications | 11.88 | July, 2020 | 开发单细胞数据分析方法 |
Single-cell transcriptomics reveals regulators underlying | Cell Research | 17.848 | July, 2020 | 研究鼻咽癌中免疫细胞多样性 |
Single-cell profiling reveals sex diversity in human renal proximal tubules | Gene | 3.331 | Aug, 2020 | 研究人肾近端小管中的性别多样性 |
Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals | Signal Transduction and Targeted Therapy | NA | Aug, 2020 | 重症和轻度个体对SARS-CoV-2感染的适应性免疫反应 |
Dysregulated adaptive immune response contributes to severe COVID-19 | Cell Research | 17.848 | Aug, 2020 | 适应性免疫失调在COVID-19重症发生中的重要作用 |
A human circulating immune cell landscape | Protein&Cell | 7.575 | Aug, 2020 | 老年COVID-19病人的免疫图谱 |
Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm | Nature communications | 11.88 | Aug, 2020 | 研究托珠单抗治疗后的COVID-19病人样本 |
Single-cell transcriptomics identifies a distinct luminal progenitor cell type in distal prostate invagination tips | Nature Genetics | 25.455 | Aug, 2020 | 研究前例腺多能干细胞 |
Single-cell RNA-Seq reveals the transcriptional landscape and heterogeneity of skin macrophages in Vsir-/- murine psoriasis | Theranostics | 8.7 | Aug, 2020 | 研究银屑病病人皮肤中的巨噬细胞 |
Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis | Protein&Cell | 7.575 | Aug, 2020 | 研究蝾螈肢体再生 |
Single-cell RNA-seq reveals the immune escape and drug | Cancer Biology & Medicine | 5.4 | Aug, 2020 | 研究淋巴瘤的耐药机制 |
Single-cell landscape of immunological responses in patients with COVID-19 | Nature immunology | 20.47 | Sep, 2020 | COVID-19患者的免疫反应的单细胞图谱 |
Pharmacologically reversible zonation-dependent | Nature communications | 11.88 | Sep, 2020 | 研究神经退行性疾病 |
Single-cell transcriptomic analysis defines the interplay between tumor cells, viral infection, and the microenvironment in nasopharyngeal carcinoma | Cell Research | 17.848 | Sep, 2020 | 揭示鼻咽癌肿瘤细胞的双重特性 |
Single-nucleus RNA-seq resolves spatiotemporal developmental trajectories in the tomato shoot apex | bioRxiv | NA | Sep, 2020 | 单细胞核测序研究番茄顶芽 |
Dimensionality reduction for single cell RNA sequencing data using constrained robust non-negative matrix factorization | NAR Genomics and Bioinformatics | NA | Sep, 2020 | 开发数据分析方法 |
Nanoparticle enhanced combination therapy for stem-like progenitors defined by single-cell transcriptomics in chemotherapy-resistant osteosarcoma | Signal Transduction and Targeted Therapy | 5.8 | Sep, 2020 | 研究骨肉瘤的治疗方法 |
Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease | PNAS | 9.58 | Sep, 2020 | 研究阿尔斯海默症 |
Single-cell transcriptomic atlas of primate cardiopulmonary aging | Cell Research | 17.848 | Sep, 2020 | 研究灵长类心肺的衰老 （单细胞核测序） |
Cell Development Deficiency and Gene Expression Dysregulation of Trisomy 21 Retina Revealed by Single-Nucleus RNA Sequencing | Frontiers in Bioengineering and Biotechnology | 4.2 | Sep, 2020 | 研究21三体综合症患者视网膜 |
Single-cell immune landscape of human recurrent spontaneous abortion | Cell Report | 7.815 | Sep, 2020 | 构建反复自然流产的单细胞免疫图谱 |
Identification of a novel cancer stem cell subpopulation that promotes progression of human fatal renal cell carcinoma by single-cell RNA-seq analysis | International Journal of Biological Sciences | 3.8 | Oct, 2020 | 研究人幼儿肾癌中的干细胞 |
Single‐Cell Transcriptomics of Engineered Cardiac Tissues From Patient‐Specific Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Abnormal Developmental Trajectory and Intrinsic Contractile Defects in Hypoplastic Right Heart Syndrome | Journal of the American Heart Association | 2.382 | Oct, 2020 | 研究iPS诱导分化的心肌细胞 |
Reclassification of classic T cell subsets and identification of novel cell types by single-cell RNA sequencing | bioRxiv | NA | Oct, 2020 | 研究外周血T细胞的亚型 |
A Unique Population of Regulatory T Cells in Heart Potentiates Cardiac Protection from Myocardial Infarction | Circulation | 23.6 | Oct, 2020 | 研究调节性T细胞在心机梗塞中的作用 |
Cell populations in neonatal rat peripheral nerves identified by single‐cell transcriptomics | Glia | 6.2 | Oct, 2020 | 研究幼年大鼠外周神经组织的细胞异质性 |
Single-cell RNA-seq data semi-supervised clustering and annotation via structural regularized domain adaptation | Bioinformatics | 4.531 | Oct, 2020 | 开发单细胞数据分析方法 |
Single-Cell RNA-Sequencing Shift in the Interaction Pattern Between Glioma Stem Cells and Immune Cells During Tumorigenesis | Frontiers in Immunology | 5 | Oct, 2020 | 研究神经胶质瘤 |
Single-Cell RNA-Seq Reveals that CD9 Is a Negative Marker of Glucose-Responsive Pancreatic β-like Cells Derived from Human Pluripotent Stem Cells | Stem Cell Reports | 6 | Oct, 2020 | 研究CD9阳性的胰岛β样细胞 |
Cell-Type Transcriptome Atlas of Human Aortic Valves Reveal Cell Heterogeneity and Endothelial to Mesenchymal Transition Involved in Calcific Aortic Valve Disease | Arteriosclerosis, Thrombosis, and Vascular Biology | 6.6 | Oct, 2020 | 研究主动脉瓣细胞异质性 |
scAIDE: clustering of large-scale single-cell RNA-seq data reveals putative and rare cell types | NAR Genomics and Bioinformatics | NA | Oct, 2020 | 开发单细胞数据分析方法 |
Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma | Nature communications | 11.88 | Oct, 2020 | 研究膀胱尿路上皮癌中的炎症相关成纤维细胞 |
Single-cell RNA-seq reveals different subsets of non-specific cytotoxic cells in teleost | Genomics | 6.2 | Nov, 2020 | 研究硬骨鱼中的细胞毒性细胞 |
An interpretable deep-learning architecture of capsule networks for identifying cell-type gene expression programs from single-cell RNA-sequencing data | Nature Machine Intelligence | 16 | Nov, 2020 | 开发单细胞数据分析方法 |
Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations | Oncogene | 6.9 | Nov, 2020 | 研究EGFR突变肺癌病人的肿瘤细胞及免疫细胞的异质性 |
scAPAtrap: identification and quantification of alternative polyadenylation sites from single-cell RNA-seq data | Briefings in Bioinformatics | 6.302 | Nov, 2020 | 开发单细胞数据分析方法 |
Single-cell transcriptome profiling reveals the mechanism of abnormal proliferation of epithelial cells in congenital cystic adenomatoid malformation | Experimental Cell Research | 3.2 | Nov, 2020 | 研究先天性囊性腺瘤样畸形 |
Single-Cell Characterization of Malignant Phenotypes and Developmental Trajectories of Adrenal Neuroblastoma | Cancer Cell | 22.844 | Nov, 2020 | 研究肾上腺神经母细胞瘤 |
Single cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma | Journal of Hepatology | 18.946 | Nov, 2020 | 研究胆管癌 |
Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells | Nature communications | 11.88 | Nov, 2020 | 研究精子发育 |
Liver immuneprofiling reveals pathogenesis and therapeutics for biliary atresia | Cell | 36.216 | Nov, 2020 | 新生儿胆道闭锁的发病机制和新的治疗策略 |
Single cell RNA and immune repertoire profiling of COVID-19 patients reveal novel neutralizing antibody | Protein&Cell | 7.575 | Nov, 2020 | 筛选高效的新冠病毒中和抗体 |
Decoding human megakaryocyte development | Cell Stem Cell | 21.464 | Dec, 2020 | 研究人类巨核细胞发育 |
Single-cell landscape of the ecosystem in earlyrelapse hepatocellular carcinoma | Cell | 36.216 | Jan, 2021 | 研究早期复发性肝细胞癌全景图谱 |
Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma | Cell Research | 17.848 | Jan, 2021 | 研究恶性神经胶质瘤的发病机理 |
Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression | Nature Cell Biology | 20.042 | Jan, 2021 | 研究前列腺发展过程中的细胞重塑 |
Single cell ATAC-Seq reveals cell type-specific transcriptional regulation and unique chromatin accessibility in human spermatogenesis | Human Molecular Genetics | 5.1 | Jan, 2021 | 研究人类精子发生 |
Decoding the multicellular ecosystem of lung adenocarcinoma manifested as pulmonary subsolid nodules by single-cell RNA sequencing | Science Advances | 13 | Jan, 2021 | 研究肺腺癌肿瘤微环境特征 |
Identification of Novel Population-Specific Cell Subsets in Chinese Ulcerative Colitis Patients Using Single-Cell RNA Sequencing | Cellular and Molecular Gastroenterology and Hepatology | 7 | Jan, 2021 | 使用单细胞 RNA 测序鉴定中国溃疡性结肠炎患者的新型种群特异性细胞亚群 |
Single-cell Immune Landscape of Human Recurrent Miscarriage | Genomics, Proteomics & Bioinformatics | 6.41 | Jan, 2021 | 人类复发性流产的单细胞免疫图谱 |
Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse | Nature communications | 11.88 | Jan, 2021 | 严重前阴道脱垂女性阴道壁的单细胞转录组分析 |
Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses | Cell Research | 17.848 | Jan, 2021 | 通过单细胞转录组学和功能分析剖析人胚胎骨骼干细胞个体发育 |
Tumour Heterogeneity and Intercellular Networks of Nasopharyngeal Carcinoma at Single Cell Resolution | Nature communications | 11.88 | Feb, 2021 | 研究鼻咽癌肿瘤微环境的细胞异质性及其动态变化 |
A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells | Cell | 36.216 | Feb, 2021 | 泛癌种尺度下肿瘤浸润髓系细胞的单细胞转录图谱 |
FlsnRNA-seq: protoplasting-free full-length single-nucleus RNA profiling in plants | Genome Biology | 13.214 | Feb, 2021 | 开发植物中的单核水平上的、大规模的全长RNA分析技术 |
Epigenetic landscapes of single-cell chromatin accessibility and transcriptomic immune profiles of T cells in COVID-19 patients | Frontiers in Immunology | 5.1 | Feb, 2021 | 研究新冠样本染色质可及性和T细胞转录组免疫图谱 |
Single-cell transcriptomes of peripheral blood cells indicate and elucidate severity of COVID-19 | Science China Life Sciences | 4.6 | Feb, 2021 | 外周血细胞的单细胞转录组指示并阐明了COVID-19的严重程度 |
Single-cell RNA sequencing reveals species-specific time spans of cell cycle transitions in early oogenesis | Human Molecular Genetics | 4.611 | Feb, 2021 | 单细胞RNA测序揭示了早期卵子发生 |
Single-Cell Transcriptome Profiling Reveals | bioRxiv | NA | Feb, 2021 | 单细胞转录组分析揭示人类脊索瘤的瘤内异质性 |
iMAP: integration of multiple single-cell datasets by adversarial paired transfer networks | Genome Biology | 13.214 | Feb, 2021 | 数据整合工具 |
Single-cell RNA-Seq revealed profound immune alteration in the peripheral blood of patients with bacterial infection | International Journal of Infectious Diseases | 3.538 | Feb, 2021 | 细菌感染患者外周血单细胞图谱 |
Single-Cell RNA Sequencing Reveals the Expansion of Cytotoxic CD4 T Lymphocytes and a Landscape of Immune Cells in Primary Sjögren’s Syndrome | Frontiers in Immunology | 6.429 | Feb, 2021 | 原发性干燥综合征中细胞毒性 CD4 T 淋巴细胞的扩增和免疫细胞的分布 |
A Single-Cell Transcriptomic Atlas of Human Skin Aging | Developmental Cell | 10.092 | Feb, 2021 | 人类皮肤衰老的单细胞转录组学图谱 |
Transcriptional landscape of rice roots at the single-cell resolution | Molecular Plant | 9.326 | Mar, 2021 | 水稻根单细胞测序 |
MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche | Nature | 41.577 | Mar, 2021 | 发现新型肠道间质细胞并揭示其在炎症过程中调控肠道干细胞损伤修复机制 |
Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE | Nature communications | 11.88 | Mar, 2021 | 开发单细胞测序分析转座元件表达的工具scTE |
Sequential progenitor states mark the generation of pancreatic endocrine lineages in mice and humans | Cell Research | 17.848 | Mar, 2021 | 研究胰腺内分泌细胞发育 |
Single-cell transcriptomic analysis of somatosensory neurons uncovers temporal development of neuropathic pain | Cell Research | 17.848 | Mar, 2021 | 研究神经性疼痛的机制 |
A single-cell analysis of the Arabidopsis vegetative shoot apex | Developmental Cell | 10.092 | Mar, 2021 | 在单细胞水平揭示了拟南芥茎尖细胞的异质性 |
Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop | Science | 37.205 | Mar, 2021 | 发现天然淋巴细胞的骨髓外发育新路径 |
Single-cell RNA sequencing reveals the cellular origin and evolutionof breast cancer in BRCA1 mutation carriers | Cancer Research | 9.13 | Mar, 2021 | 揭示乳腺癌的细胞起源和进化 |
A single-cell survey of the human glomerulonephritis | Journal of Cellular and Molecular Medicine | 4.658 | Mar, 2021 | 研究人类肾小球肾炎 |
Single-cell transcriptomics uncovers phenotypic alterations in the monocytes in a Chinese population with chronic cadmium exposure | Ecotoxicology and Environmental Safety | 6.291 | Mar, 2021 | 单细胞转录组学揭示慢性镉暴露中国人群单核细胞的表型改变 |
Single-Cell Transcriptome Analysis Uncovers Intratumoral Heterogeneity and Underlying Mechanisms for Drug Resistance in Hepatobiliary Tumor Organoids | Advanced Science | 16.806 | Mar, 2021 | 单细胞转录组分析揭示了肝胆肿瘤类器官的肿瘤内异质性和耐药机制 |
Single-Cell Transcriptome Atlas and Chromatin Accessibility Landscape Reveal Differentiation Trajectories in the Rice Root | Nature communications | 11.88 | Apr, 2021 | 水稻根单细胞异质性和分化全景图 |
COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas | Cell | 36.216 | Apr, 2021 | 研究COVID-19病人免疫系统 |
Identification of Silkworm Hemocyte Subsets and Analysis of Their Response to Baculovirus Infection Based on Single-Cell RNA Sequencing | Frontiers in Immunology | 5.1 | Apr, 2021 | 家蚕血细胞亚群的鉴定及其对杆状病毒感染的反应分析 |
A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish | PNAS | 9.4 | Apr, 2021 | 单细胞水平揭示了斑马鱼造血干细胞扩增的动态图谱 |
Atlas of breast cancer infiltrated B-lymphocytes revealed by paired single-cell RNA-sequencing and antigen receptor profiling | Nature communications | 11.88 | Apr, 2021 | 揭示的乳腺癌浸润 B 淋巴细胞图谱 |
Identifying the functions of two biomarkers in human oligodendrocyte progenitor cell development | Journal of | 4.2 | May, 2021 | 研究少突胶质祖细胞发育 |
Molecular identity of human limbal heterogeneity involved in corneal homeostasis and privilege | Ocular Surface | 12.336 | May, 2021 | 研究人角膜干细胞及微环境 |
Coupled analysis of transcriptome and BCR mutations reveals role of OXPHOS in affinity maturation | Nature immunology | 20.47 | May, 2021 | 揭示了氧化磷酸化通路在生发中心B细胞亲和力正向筛选中的关键作用。 |
Mouse totipotent stem cells captured and maintained through spliceosomal repression | Cell | 36.216 | May, 2021 | 小鼠ESCs剪接体抑制驱动多能到全能状态转换 |
Single-cell transcriptomes reveal characteristic features of cell types within the human adrenal microenvironment | Journal of Cellular Physiology | 5.546 | May, 2021 | 单细胞转录组揭示人类肾上腺微环境中细胞类型的特征 |
Global characterization of B cell receptor repertoire in COVID-19 patients by single-cell V(D)J sequencing | Briefings in Bioinformatics | 11.622 | May, 2021 | COVID-19 患者B细胞受体库 |
Single-cell RNA sequencing reveals the sustained immune cell dysfunction in the pathogenesis of sepsis secondary to bacterial pneumonia | Genomics | 5.736 | May, 2021 | 揭示细菌性肺炎继发脓毒症发病机制中持续的免疫细胞功能障碍 |
Single-cell transcriptome atlas of the leaf and root of rice seedlings | Journal of Genetics and Genomics | 4.65 | Jun, 2021 | 绘制单子叶模式植物水稻的单细胞转录图谱 |
The chromosome-level reference genome of Coptis chinensis provides insights into genomic evolution and berberine biosynthesis | Horticulture Research | 5.676 | Jun, 2021 | 构建黄连的参考基因组 |
Single-cell RNA-seq describes the transcriptome landscape and identifies critical transcription factors in the leaf blade of the allotetraploid peanut (Arachis hypogaea L.) | Plant Biotechnology Journal | 9.803 | Jun, 2021 | 花生叶片组织单细胞图谱 |
Hypoxic microenvironment induced spatial transcriptome changes in pancreatic cancer | Cancer Biology & Medicine | 4.248 | Jun, 2021 | 缺氧微环境诱导胰腺癌组织内空间转录组的变化 |
Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway | Journal of Neuroinflammation | 8.322 | Jun, 2021 | Smek1缺乏通过激活促炎性小胶质细胞和抑制IDO1-AhR途径加重实验性自身免疫性脑脊髓炎 |
Single-cell analyses reveal suppressive tumor microenvironment of human colorectal cancer | Clinical and Translational Medicine | 11.492 | Jun, 2021 | 单细胞分析揭示了人类结直肠癌的抑制性肿瘤微环境 |
Single-Cell RNA-seq Identification of the Cellular Molecular Characteristics of Sporadic Bilateral Clear Cell Renal Cell Carcinoma | Frontiers in Oncology | 6.244 | Jun, 2021 | 散发性双侧透明细胞肾细胞癌细胞单细胞图谱 |
Single-Cell Transcriptomic Analysis Reveals a Hepatic Stellate Cell–Activation Roadmap and Myofibroblast Origin During Liver Fibrosis in Mice | Hepatology | 17.425 | Jun, 2021 | 小鼠肝纤维化过程中的肝星状细胞激活路线图和肌成纤维细胞起源 |
Single-cell transcriptomic analysis reveals disparate effector differentiation pathways in human Treg compartment | Nature communications | 11.88 | Jun, 2021 | 单细胞转录组学分析揭示了人类 Treg |
Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells | Cell Research | 17.848 | Jul, 2021 | 解析人类固有淋巴细胞起源 |
The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation | Immunity | 31.745 | Jul, 2021 | 锌指蛋白Miz1通过限制肝细胞驱动的巨噬细胞活化和炎症来抑制肝脏肿瘤发生 |
Single-cell atlas of domestic pig cerebral cortex and hypothalamus | Science Bulletin | 11.78 | Jul, 2021 | 家猪大脑皮层和下丘脑的单细胞图谱 |
Single-cell spatial transcriptomic analysis reveals common and divergent features of developing postnatal granule cerebellar cells and medulloblastoma | BMC Biology | 5.914 | Jul, 2021 | 单细胞空间转录组学分析揭示了出生后颗粒小脑细胞和成神经管细胞瘤的共同和不同特征 |
Identification of HSC/MPP expansion units in fetal liver by single-cell spatiotemporal transcriptomics | Cell Research | 17.848 | Aug, 2021 | 研究胎儿肝脏中的造血干细胞和多能干细胞 |
Multiomic analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn’s disease | Immunity | 31.745 | Aug, 2021 | 肝细胞癌肿瘤微环境 |
Single-cell transcriptomic landscape reveals tumor specific innate lymphoid cells associated with colorectal cancer progression | Cell Report | 7.815 | Aug, 2021 | 结直肠癌天然淋巴细胞图 |
Insulin signaling establishes a developmental trajectory of adipose regulatory T cells | Nature immunology | 20.47 | Aug, 2021 | 揭示脂肪组织Treg不同亚型分化及其功能调控新机制 |
Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level | Cancer Discovery | 39.4 | Aug, 2021 | 结直肠癌肝转移的免疫动态变化 |
A versatile and scalable single-cell data integration algorithm based on domain-adversarial and variational approximation | Briefings in Bioinformatics | 11.622 | Sep, 2021 | 开发数据分析工具 |
Transcriptomic Landscape of Circulating Mononuclear Phagocytes in Langerhans Cell Histiocytosis at Single-cell Level | Blood | 17.794 | Oct, 2021 | 解析LCH单核吞噬系统转录组特征 |
CancerSCEM: a database of single-cell expression map across various human cancers | Nucleic Acids Research | 16.971 | Oct, 2021 | 数据集 |
Single Cell and Plasma RNA Sequencing for RNA Liquid Biopsy for Hepatocellular Carcinoma | Cancer Diagnostics | 8.327 | Nov, 2021 | 肝癌液体活检 |
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